Annals of the Rheumatic Diseases May 2012, Volume 71, Issue 5

	Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis Angelika Horn, Trayana Kireva, Katrin Palumbo-Zerr, Clara Dees, Michal Tomcik, Cinzia Cordazzo, Pawel Zerr, Alfiya Akhmetshina, Martial Ruat, Oliver Distler, Christian Beyer,Georg Schett, Jörg H W Distler Abstract
	Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1and HLA-G Michelle M A Fernando, Jan Freudenberg, Annette Lee, David Lester Morris, Lora Boteva,Benjamin Rhodes, María Francisca Gonzalez-Escribano, Miguel Angel Lopez-Nevot,Sandra V Navarra, Peter K Gregersen, Javier Martin, IMAGEN, Timothy J Vyse Abstract
	Combination of IL-17 and TNFα induces a pro-inflammatory, pro-coagulant and pro-thrombotic phenotype in human endothelial cells Arnaud Hot, Vanina Lenief, Pierre Miossec Abstract
	Beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis Christian Beyer, Amelie Schramm, Alfiya Akhmetshina, Clara Dees, Trayana Kireva, Kolja Gelse, Sonali Sonnylal, Benoit de Crombrugghe, Makoto Mark Taketo, Oliver Distler,Georg Schett, Jörg H W Distler Abstract
	Impact of IL-1 signalling on experimental uveitis and arthritis Stephen R Planck, April Woods, Jenna S Clowers, Martin J Nicklin, James T Rosenbaum, Holly L Rosenzweig Abstract
	Extended report: Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathy Anthony N Corps, Andrew H N Robinson, Rebecca L Harrall, Nicholas C Avery, Valerie A Curry, Brian L Hazleman, Graham P Riley Abstract
	Extended report: Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis Nicole Reich, Michal Tomcik, Pawel Zerr, Veronika Lang, Clara Dees, Jérome Avouac,Katrin Palumbo, Angelika Horn, Alfiya Akhmetshina, Christian Beyer, Weilin Xie, Brydon L Bennett, Oliver Distler, Georg Schett, Jörg H W Distler Abstract
	Extended report: Endothelial cells present an innate resistance to glucocorticoid treatment: implications for therapy of primary vasculitis Paola Koenen, Katarzyna Barczyk, Marc Wolf, Johannes Roth, Dorothee Viemann Abstract
	Extended report: Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo Kirsten Braem, Frank P Luyten, Rik J U Lories Abstract
	Concise report: Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry Christopher P Denton, Thomas Krieg, Loic Guillevin, Barbara Schwierin, Daniel Rosenberg, Mariabeth Silkey, Maurice Zultak, Marco Matucci-Cerinic Abstract
	Concise report: A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis Roberto Díaz-Peña, Ana M Aransay, Beatriz Suárez-Álvarez, Jacome Bruges-Armas,Naiara Rodríguez-Ezpeleta, María Regueiro, Fernando M Pimentel-Santos, Juan Mulero,Alejandra Sánchez, Eduardo Collantes, Rubén Queiro, Javier Ballina, Helena Alves,Carlos López-Larrea Abstract
	Concise report: Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy Yuki Ichimura, Takashi Matsushita, Yasuhito Hamaguchi, Kenzo Kaji, Minoru Hasegawa,Yoshinori Tanino, Yayoi Inokoshi, Kazuhiro Kawai, Takuro Kanekura, Maria Habuchi,Atsuyuki Igarashi, Ryosuke Sogame, Takashi Hashimoto, Tomohiro Koga, Ayako Nishino, Naoko Ishiguro, Naoki Sugimoto, Rui Aoki, Noriko Ando, Tetsuya Abe, Takashi Kanda, Masataka Kuwana, Kazuhiko Takehara, Manabu Fujimoto Abstract
	Concise report: Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study Rachel Knevel, Gerður Gröndal, Tom W J Huizinga, A Willemien Visser, Helgi Jónsson,Arnór Víkingsson, Árni Jón Geirsson, Kristján Steinsson, Annette H M van der Helm-van Mil Abstract
	Extended report: Early response to adalimumab predicts long-term remission through 5 years of treatment in patients with ankylosing spondylitis Joachim Sieper, Désirée van der Heijde, Maxime Dougados, L Steve Brown, Frederic Lavie, Aileen L Pangan Abstract
	Extended report: Analysis of autosomal genes reveals gene–sex interactions and higher total genetic risk in men with systemic lupus erythematosus Travis Hughes, Adam Adler, Joan T Merrill, Jennifer A Kelly, Kenneth M Kaufman,Adrienne Williams, Carl D Langefeld, Gary S Gilkeson, Elena Sanchez, Javier Martin,Susan A Boackle, Anne M Stevens, Graciela S Alarcón, Timothy B Niewold, Elizabeth E Brown, Robert P Kimberly, Jeffrey C Edberg, Rosalind Ramsey-Goldman, Michelle Petri,John D Reveille, Lindsey A Criswell, Luis M Vilá, Chaim O Jacob, Patrick M Gaffney, Kathy L Moser, Timothy J Vyse, Marta E Alarcón-Riquelme, Judith A James, Betty P Tsao, R Hal Scofield, John B Harley, Bruce C Richardson, Amr H Sawalha Abstract
	Extended report: Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction Josef S Smolen, José C Martinez Avila, Daniel Aletaha Abstract
	Extended report: Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort Siri Lillegraven, Femke HM Prince, Nancy A Shadick, Vivian P Bykerk, Bing Lu, Michelle L Frits, Christine K Iannaccone, Tore K Kvien, Espen A Haavardsholm, Michael E Weinblatt,Daniel H Solomon Abstract
	Extended report: Serum markers associated with clinical improvement in patients with ankylosing spondylitis treated with golimumab Carrie Wagner, Sudha Visvanathan, Jürgen Braun, Désirée van der Heijde, Atul Deodhar,Benjamin Hsu, Michael Mack, Michael Elashoff, Robert D Inman Abstract
	Extended report: Physical activity and physical activity cognitions are potential factors maintaining fatigue in patients with primary Sjögren’s syndrome Eveline JM Wouters, Ninke van Leeuwen, Ercolie R Bossema, Aike A Kruize, Hendrika Bootsma, Johannes WJ Bijlsma, Rinie Geenen Abstract
	Extended report: Golimumab administered subcutaneously every 4 weeks in ankylosing spondylitis: 104-week results of the GO-RAISE study Jürgen Braun, Atul Deodhar, Robert D Inman, Désirée van der Heijde, Michael Mack,Stephen Xu, Benjamin Hsu Abstract
	Extended report: Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study Andrew K Wills, Stephanie Black, Rachel Cooper, Russell J Coppack, Rebecca Hardy,Kathryn Remmes Martin, Cyrus Cooper, Diana Kuh Abstract
	Extended report: Use of statins is associated with an increased risk of rheumatoid arthritis H J I de Jong, O H Klungel, L van Dijk, R J Vandebriel, H G M Leufkens, JW van der Laan,J W Cohen Tervaert, H van Loveren Abstract
	Extended report: Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study S Clockaerts, G J V M Van Osch, Y M Bastiaansen-Jenniskens, J A N Verhaar, F Van Glabbeek, J B Van Meurs, H J M Kerkhof, A Hofman, B H Ch Stricker, S M Bierma-Zeinstra Abstract
	EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis Danielle M Gerlag, Karim Raza, Lisa G M van Baarsen, Elisabeth Brouwer, Christopher D Buckley, Gerd R Burmester, Cem Gabay, Anca I Catrina, Andrew P Cope, François Cornelis, Solbritt Rantapää Dahlqvist, Paul Emery, Stephen Eyre, Axel Finckh, Steffen Gay, Johanna M Hazes, Annette van der Helm-van Mil, Tom W J Huizinga, Lars Klareskog, Tore K Kvien, Cathryn Lewis, Klaus P Machold, Johan Rönnelid, Dirkjan van Schaardenburg, Georg Schett, Josef S Smolen, Sue Thomas, Jane Worthington, Paul P Tak Abstract